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Paul Talalay and colleagues found that treatment of human ARPE-19 adult retinal pigment epithelial cells and HaCaT keratinocytes with nontoxic doses of SFN produced an approximate twofold increase in GSH levels that was sustained for several days and provided prolonged protection against oxidants and electrophiles, such as menadione, tert -butylhydroperoxide, 4-hydroxynonenal, and peroxynitrite [42]